Heide Schatten - Animal Models and Human Reproduction in DJV, EPUB, FB2
9781118881606 English 1118881605 Our knowledge of Reproductive Biology has increased enormously in recent years on cellular, molecular, and genetic levels and has led to significant breakthroughs that directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems. Much of our knowledge has come from model organisms that led to advances in human reproduction such as human IVF. Mammalian and non-mammalian model systems have provided a wealth of new information to build the foundation for clinical and other practical applications for humans. This includes ART, embryo transfer, and other advances that allowed for new technologies to increase agricultural productivity, and to new approaches to overcome and treat human infertility. Investigators involved in clinical applications have learned from studies in animal models which had been part of the success leading to increased reproductive efficiency in animals and in humans. Somatic cell nuclear transfer, first explored in amphibians, has resulted in producing specific stem cell populations that are likely to benefit patient-specific therapies. The cryopreservation of sperm and egg cells as well as cryopreservation of pre-implantation embryos first explored in animal models, has allowed cancer patients exposed to radiation to pursue their reproductive capacities and produce healthy offspring without being affected by radiation. Furthermore, transgenic animals have contributed to agricultural advances and have allowed the study of disease as well as creating livestock with increased nutritional value. Animal models have also provided basic information that allowed important breakthrough to advance our understanding of human reproduction, developmental abnormalities, environmental effects on the growing embryo and prenatal diagnostics to repair defects in utero. New research on reproductive aging has led to new insights and new methods to extend the reproductive lifespan which is important for animals and for humans. These advances as well as numerous others have resulted in considerably increased interest in reproduction. Animal Models and Human Reproduction contains 21 chapters written by experts in their respective fields and contains chapters on topics that are not readily available in the literature including chapters on dog reproduction, cow, pig, equine, frog, and mouse models of reproduction, covering frontier research in placental biology, ovarian function and fertility, non-coding RNAs in gametogenesis, oocyte and embryo metabolism, fertilization, cryopreservation, signal transduction pathways, chromatin dynamics, epigenetics, reproductive aging, inflammation, and others. This book will be of interest to the large societies of human reproduction, cell and molecular biology communities, and the stem cell biology community that depends on cell and molecular information of animal models to advance research of animal cloning and production of tissue-specific stem cells., Reproductive biology of animal models includes biological aspects of reproduction in domestic and laboratory animal models as well as non-human primates and non-mammalian species with reference to humans which is of interest to a large group of investigators, students, clinicians, and numerous others including established investigators or newcomers to the field. The book will include the most commonly used animal models such as mouse, rat, pig, sheep, bovine, cat, dog, horse, non-human primates, and the zebrafish, amphibian, Drosophila , C elegans , and sea urchin models. These animals are either used for basic research on reproduction or as models for humans. Some, such as the sea urchin and mice, have been used as classic models for several decades to study cellular and molecular processes that are not easily performed in mammalian systems. We will include full chapters on non-human primates with reference to human reproduction that has become of significant interest, as in vitro fertilization (IVF) is being applied increasingly, and as reproductive disorders are becoming more and more recognized as causes for infertility that may be overcome through specific assisted reproductive technologies. Differences exist in the reproductive systems of different animal species that will be addressed in the different chapters. Cross-species information is important to further advance the field and address in vitro fertilization for dogs and horses that still face more difficulties than other animal species and are of interest to reproductive scientists.
9781118881606 English 1118881605 Our knowledge of Reproductive Biology has increased enormously in recent years on cellular, molecular, and genetic levels and has led to significant breakthroughs that directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems. Much of our knowledge has come from model organisms that led to advances in human reproduction such as human IVF. Mammalian and non-mammalian model systems have provided a wealth of new information to build the foundation for clinical and other practical applications for humans. This includes ART, embryo transfer, and other advances that allowed for new technologies to increase agricultural productivity, and to new approaches to overcome and treat human infertility. Investigators involved in clinical applications have learned from studies in animal models which had been part of the success leading to increased reproductive efficiency in animals and in humans. Somatic cell nuclear transfer, first explored in amphibians, has resulted in producing specific stem cell populations that are likely to benefit patient-specific therapies. The cryopreservation of sperm and egg cells as well as cryopreservation of pre-implantation embryos first explored in animal models, has allowed cancer patients exposed to radiation to pursue their reproductive capacities and produce healthy offspring without being affected by radiation. Furthermore, transgenic animals have contributed to agricultural advances and have allowed the study of disease as well as creating livestock with increased nutritional value. Animal models have also provided basic information that allowed important breakthrough to advance our understanding of human reproduction, developmental abnormalities, environmental effects on the growing embryo and prenatal diagnostics to repair defects in utero. New research on reproductive aging has led to new insights and new methods to extend the reproductive lifespan which is important for animals and for humans. These advances as well as numerous others have resulted in considerably increased interest in reproduction. Animal Models and Human Reproduction contains 21 chapters written by experts in their respective fields and contains chapters on topics that are not readily available in the literature including chapters on dog reproduction, cow, pig, equine, frog, and mouse models of reproduction, covering frontier research in placental biology, ovarian function and fertility, non-coding RNAs in gametogenesis, oocyte and embryo metabolism, fertilization, cryopreservation, signal transduction pathways, chromatin dynamics, epigenetics, reproductive aging, inflammation, and others. This book will be of interest to the large societies of human reproduction, cell and molecular biology communities, and the stem cell biology community that depends on cell and molecular information of animal models to advance research of animal cloning and production of tissue-specific stem cells., Reproductive biology of animal models includes biological aspects of reproduction in domestic and laboratory animal models as well as non-human primates and non-mammalian species with reference to humans which is of interest to a large group of investigators, students, clinicians, and numerous others including established investigators or newcomers to the field. The book will include the most commonly used animal models such as mouse, rat, pig, sheep, bovine, cat, dog, horse, non-human primates, and the zebrafish, amphibian, Drosophila , C elegans , and sea urchin models. These animals are either used for basic research on reproduction or as models for humans. Some, such as the sea urchin and mice, have been used as classic models for several decades to study cellular and molecular processes that are not easily performed in mammalian systems. We will include full chapters on non-human primates with reference to human reproduction that has become of significant interest, as in vitro fertilization (IVF) is being applied increasingly, and as reproductive disorders are becoming more and more recognized as causes for infertility that may be overcome through specific assisted reproductive technologies. Differences exist in the reproductive systems of different animal species that will be addressed in the different chapters. Cross-species information is important to further advance the field and address in vitro fertilization for dogs and horses that still face more difficulties than other animal species and are of interest to reproductive scientists.